Polymyositis and dermatomyositis associated with the etiology of mental disorders, polymyositis and dermatomyositis associated with mental disorders are caused by what the cause

polymyositis and dermatomyositis associated with mental disorders are caused by what the?

(a) causes

Polymyositis is a connective tissue disease of unknown cause, is now considered an autoimmune disease, in recent years that the cellular immune defects have important pathogenic significance, was that the disease is closely related with cancer , has also been reported in 40 patients with dermatomyositis over the age of 50% of the combined cancer, may have pathogenic significance of vascular injury, infection, sunlight, drugs and other factors to induce, polymyositis is associated with the onset of mental disorders the main factors leading to mental disorders secondary to brain dysfunction physical disease, but patients suffering from polymyositis occurred only a few mental disorders, it is associated with polymyositis are not their only cause of mental disorders, there are other factors and the occurrence of mental disorders, such as other biological factors, including patients gender, age, genetic factors, personality characteristics, and past history of mental illness and other neurological; psychological factors including stress, long-term psychological contradictions; environment factors such as overcrowding, environmental noise, humidity, air pollution, these factors can be associated with mental disorders polymyositis precipitating factor.

(B) the pathogenesis

studies have shown that parts of the immune response of polymyositis beginning in connective tissue, then spread to the muscles, skin, blood vessels, heart, serosa and nervous system, in electron microscopy, in this disease, muscle and skin vascular endothelial cells and found a similar sticky sticky virus, virus or virus-like particles, but polymyositis associated with the pathogenesis of mental disorders, lack of evidence, because of polymyositis associated with mental disorders are mental disorders associated with physical disease Therefore, physical illness associated with the pathogenesis of mental disorders in general whether to provide a reference?

1. energy supply shortage of mental disorders associated with physical disease common pathophysiological changes of diffuse brain changes in energy demand, due to metabolism disorders caused by physical disease, leading to energy supply, while the brain is very sensitive to the energy requirements, when physical suffering from the disease, the brain growth in demand for energy, then the body from energy supply and demand, resulting in normal physiological function of the brain disorder, which is such that the main mechanism of mental disorders.

2. cerebral hypoxia physical diseases, particularly cardiovascular disease, caused by the body and brain circulation disorders, lung disease or anemia resulting lack of oxygen carrying capacity, or the body in the microcirculation under the influence of harmful factors, etc., can lead to cerebral blood supply, lack of oxygen to cerebral dysfunction, which is an important mechanism for the occurrence of mental disorders.

3. biotoxins role of physical disease, due to exogenous substances such as bacteria, viruses, parasites, chemicals, toxic gases, and other invasive organism, its toxins or metabolic intermediates directly on brain cells, causing brain cells affected by damage and cerebral disorders lead to mental disorders.

certain bacteria, viruses, toxins produced by the central nervous system has a strong affinity, has resulted in mental disorders, and certain physical illnesses caused by the body of ammonia, indole, pyruvic acid and other toxic metabolites accumulate, affecting the normal brain functional activities are also factors leading to the occurrence of mental disorders.

4. body metabolism when physical disease, fluid and acid-base balance disorders such as metabolic acidosis, alkalosis, hypokalemia, and hyperammonemia, hormone changes, such as adrenocorticotropic hormone, cortisol, estrogen hormone, progesterone, prolactin, thyroid hormone levels and other dramatic changes, and lack of certain vitamins can lead to metabolic activity disorder, thereby affecting the metabolism, and energy supply, is bound to affect brain function and neurological disorders.

5. stress physical disease, exogenous harmful factors, including biological stressors and psychological stressors acting on the body, through the nerve physiology, neurological and biochemical, neuroendocrine, and immune system, resulting in a series of physiological biochemical reactions, in these reactions in the brain or directly involved or indirectly involved, leading to its normal physiological functions are affected, leading to the occurrence of mental disorders.

6. central neurotransmitter changes in physical disease, some hazardous substances, drugs or substances the body must be a direct result of lack of monoamine neurotransmitters in the brain metabolic abnormalities, such as the role of manganese in the globus pallidus and selective as Hill, inhibit the activity of dopamine decarboxylase leaving the dopamine content decreased, the blood disease porphyria and pellagra associated with mental disorders are found at different levels of tryptophan metabolism, hepatic encephalopathy, some of the neuropsychiatric symptoms related neurotransmitters may also, in the course of certain diseases to be produced by neurotransmitters such as hydroxyl phenylethanolamine such as phenylephrine and norepinephrine, when they interfere with the transmission of norepinephrine when the patient will be emotional, behavior and consciousness; in the transfer process to be false when the neurotransmitter dopamine replacement may occur after the flapping tremor or tremor of paralysis.

7. individual susceptibility to clinical can also see the fact that the population suffer from various infectious diseases, the probability is very high, but only a very small number of patients with infectious diseases, mental disorder; the contrary, there are many different patients with the same physical disorders appear the same in both forms of delirium symptoms, which may be genetic factors and individual qualities or personality defects, mental disorders due to physical illness such as family history accounted for 2% to 8%, higher than the general population; introverted, irritable, stubborn, headstrong person prone to physical illness mental disorders; those poor stability of brain function, such as the elderly and children prone to physical illness such as delirium.